Micellar solubilisation enhances the antiinflammatory activities of curcumin and boswellic acids in rats with adjuvant-induced arthritis

Using advanced micellation technology, stable solubilisates of curcumin and boswellia extracts with markedly enhanced bioavailability were prepared. The drugs were given daily for 3 weeks, starting from the day of Freund complete adjuvant innoculation. Solubilized curcumin showed a reduction in paw volume, tumor necrosis factor-α, interleukin-6 and C-reactive protein, myloperoxidase and lipid peroxidation markers as well as an increase in total antioxidant capacity, an effect which wass equivalent to diclofenac. The native forms showed no significant effect compared to control untreated groups.