Sex-specific effects of prepubertal stress and high-fat diet on leptin signaling in rats

- Early life stress and chronic high-fat diet are important contributors to obesity.
- Prepubertal stress and high-fat diet induced sex-specific metabolic responses.
- Both factors affect leptin signaling in a sex-specific manner.
- High-fat diet effects were more pronounced in males.
- In contrast, early life stress effects predominated in females.