Standard triple therapy versus sequential therapy for eradication of Helicobacter pylori in treatment naïve and retreat patients

The intention-to-treat eradication rate was better in sequential therapy group 84.6% than triple therapy 68% (p < 0.001). Eradication rates were significantly higher for treatment naive than retreat patients in triple therapy group (70.5% and 58.3%, respectively, p < 0.01). A trend of a better response was observed in eradication rate for treatment naive 88.55% versus retreat 74.6% in sequential therapy group but was not statistically significant (p = 0.76). Compliance was similar in the two groups, however side effects were less and the clinical response was better in the sequential therapy group.