Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8724734 | Clinical Gastroenterology and Hepatology | 2018 | 34 Pages |
Abstract
In an analysis of cases of herbal and dietary supplement-induced liver injury in Spain, we found cases to be more frequent among young women than older patients or men, and to associate with hepatocellular injury and high levels of transaminases. Herbal and dietary supplement-induced liver injury is more severe than other types of DILI and re-exposure is more likely. Increasing awareness of the hepatoxic effects of herbal and dietary supplements could help physicians make earlier diagnoses and reduce the risk of serious liver damage.
Keywords
Council for International Organizations of Medical SciencesRoussel Uclaf Causality Assessment MethodRUCAMCIOMSULNALFGGTRe-challengeALTAASHDSASTAspartate aminotransferaseDrug-induced liver injuryalanine transaminaseALPAlkaline phosphataseClinical presentationAnabolic androgenic steroidsUpper limit of normalDILICAMHepatotoxicitycomplementary and alternative medicineAcute liver failuregamma-glutamyl transpeptidase
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Authors
Inmaculada Medina-Caliz, Miren Garcia-Cortes, Andres Gonzalez-Jimenez, Maria R. Cabello, Mercedes Robles-Diaz, Judith Sanabria-Cabrera, Rocio Sanjuan-Jimenez, Aida Ortega-Alonso, Beatriz GarcÃa-Muñoz, Inmaculada Moreno, Miguel Jimenez-Perez,