Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8726739 | Gastroenterology | 2018 | 18 Pages |
Abstract
In a systematic review and network meta-analysis of trials of patients with GERD, we found LNF to have the greatest ability to improve physiologic parameters of GERD, including increased LES pressure and decreased percent time pH <4. Although TIF produced the largest increase in health-related quality of life, this could be due to the shorter follow-up time of patients treated with TIF vs LNF or PPIs. TIF is a minimally invasive endoscopic procedure, yet based on evaluation of benefits vs risks, we do not recommend it as a long-term alternative to PPI or LNF treatment of GERD.
Keywords
EndoluminalLESCRIPPILESPSUCRAtransoral incisionless fundoplicationGERDRCTHRQOLLNFTIFNMARandomized controlled trialLower esophageal sphinctergastroesophageal reflux diseaselower esophageal sphincter pressureLaparoscopic Nissen fundoplicationNetwork meta-analysisEsophagusProton pump inhibitorodds ratioHealth-related quality of life
Related Topics
Health Sciences
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Gastroenterology
Authors
Joel E. Richter, Ambuj Kumar, Seth Lipka, Branko Miladinovic, Vic Velanovich,