| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8726757 | Gastroenterology | 2018 | 36 Pages |
Abstract
In studies of intestinal epithelial tissues from patients with CD and embryonic fibroblasts from mice, along with enteroids and human IEC lines, we found that induction of cell stress alters the cytoskeleton in IECs via changes in the actin-binding proteins VIL1 and GSN. Acute changes in actin dynamics increase IEC survival, whereas long-term changes in actin dynamics lead to IEC death and intestinal inflammation. IRGM regulates necroptosis and release of DAMPs to induce gastrointestinal inflammation, linking IRGM activity with CD.
Keywords
ISRTNFIrgm1eIF2aAIECDKOIBDDAMPMEFeGFPDTTdamage-associated molecular patternsCrohn’s diseasedouble knock outdithiothreitolSmall intestineintestinal epithelial celleukaryotic translation initiation factor 2tumor necrosis factormouse embryonic fibroblastknock outwild typeIntegrated stress responseImmune responseenhanced green fluorescent proteinCytoskeletonIEC
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Authors
Swati Roy, Amin Esmaeilniakooshkghazi, Srinivas Patnaik, Yaohong Wang, Sudeep P. George, Afzal Ahrorov, Jason K. Hou, Alan J. Herron, Hiromi Sesaki, Seema Khurana,