Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8726767 | Gastroenterology | 2018 | 60 Pages |
Abstract
Levels of KLF5 are increased in human PDAC samples and in PanINs of Ptf1a-CreERTM;LSL-KrasG12D mice, compared with controls. KLF5 disruption increases expression of NDRG2 and reduces activation of STAT3 and reduces ADM and PanINs formation in mice. Strategies to reduce KLF5 activity might reduce progression of acinar cells from ADM to PanIN and pancreatic tumorigenesis.
Keywords
PI3KCyclin D1ADMqRT-PCRCCND1shRNAKRASqPCRacinar-to-ductal metaplasiaKLFDMSOshort hairpin RNAPancreatic ductal adenocarcinomaPDAC یا pancreatic ductal adenocarcinomaOncogenechromatin immunoprecipitationImmunofluorescenceIHCimmunohistochemicalGene regulationDimethyl sulfoxideKirsten rat sarcoma viral oncogene homologKrüppel-like factorMEKpancreatic intraepithelial neoplasiaSignal transductionQuantitative reverse-transcriptase polymerase chain reactionquantitative polymerase chain reactionPancreasPanINmitogen-activated protein kinase kinaseCHiP
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Authors
Ping He, Jong Won Yang, Vincent W. Yang, Agnieszka B. Bialkowska,