| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8726769 | Gastroenterology | 2018 | 44 Pages |
Abstract
GAL3 activates PSC cells to produce inflammatory cytokines via ITGB1signaling to ILK and activation of NF-κB. Inhibition of this pathway reduced growth and metastases of pancreatic orthotopic tumors in mice.
Keywords
qPCRTMEGEOITGB1PSCGAL3mRNAMCPCXCL1CCL2Chemokine ligand 1C-C Motif Chemokine Ligand 2α-SMAECMEGFRCondition mediumQuantitative PCRmessenger RNAPancreatic ductal adenocarcinomaPDAC یا pancreatic ductal adenocarcinomaILKinterleukinEnzyme-linked immunosorbent assayELISApancreatic stellate cellPancreatic Stellate Cellsnuclear factorExtracellular matrixMouse modelTumor microenvironmentpolymerase chain reactionPCRModified citrus pectinGene Expression Omnibusintegrin-linked kinasegalectin 3Galectin-3Epidermal growth factor receptor
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Authors
Wei Zhao, Jaffer A. Ajani, Guha Sushovan, Nobuo Ochi, Rosa Hwang, Margarete Hafley, Randy L. Johnson, Robert S. Bresalier, Craig D. Logsdon, Zhiqian Zhang, Shumei Song,