Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8726832 | Gastroenterology | 2018 | 47 Pages |
Abstract
Pancreatic cancer is accompanied by a fibrotic reaction that alters interactions between tumor cells and the stroma to promote tumor progression. Consequently, strategies to target the tumor stroma might be used to treat patients with pancreatic cancer. We review recently developed approaches for reshaping the pancreatic tumor stroma and discuss how these might improve patient outcomes. We also describe relationships between the pancreatic tumor extracellular matrix, the vasculature, the immune system, and metabolism, and discuss the implications for the development of stromal compartmentâspecific therapies.
Keywords
actAKPCCAFMMPCEVFDG PETPSCECMdiagnostic toolHyaluronic acidα-smooth muscle actinLOXTAMInvasionRho kinasePancreatic cancerpancreatic stellate cellVascular endothelial growth factorVascular Endothelial Growth Factor (VEGF)Cancer-associated fibroblastsLysyl oxidaseExtracellular matrixmatrix metalloproteinaseTumor-associated macrophageMetastasisRock
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Authors
Claire Vennin, Kendelle J. Murphy, Jennifer P. Morton, Thomas R. Cox, Marina Pajic, Paul Timpson,