| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8726904 | Gastroenterology | 2018 | 48 Pages |
Abstract
NVR3-778 has high antiviral activity in mice with humanized livers and stable HBV infection, reducing levels of serum HBV DNA and HBV RNA. Entecavir reduced levels of serum HBV DNA, but had no effect on HBV RNA. The combination of NVR3-778 and peg-IFN prevented viral replication and HBV RNA particle production to a greater extent than each compound alone or entecavir.
Keywords
DAArcDNArelaxed circular DNApgRNAHBcAgcccDNAISGuPAPEG-IFNHBsAgHBeAgSCIDALTETVcovalently closed circular DNApregenomic RNAAlanine aminotransferasehuman albuminHepatitis B surface antigenEntecavirpegylated interferon alphaCAMendoplasmatic reticulumurokinase-type plasminogen activatorReplicationhepatitis B core antigenHBVhepatitis B virusER stress responseinterferon-stimulated geneHAp
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Authors
Klaus Klumpp, Takashi Shimada, Lena Allweiss, Tassilo Volz, Marc Lütgehetmann, George Hartman, Osvaldo A. Flores, Angela M. Lam, Maura Dandri,