Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8726908 | Gastroenterology | 2018 | 14 Pages |
Abstract
PDAC cells produce IL35 to recruit monocytes via CCL5 and induce macrophage to promote angiogenesis via expression of CXCL1 and CXCL8. IL35 signaling promotes angiogenesis and growth of xenograft tumors from PDAC cells in mice. IL35 might serve as a therapeutic target for patients with pancreatic cancer.
Keywords
MLCTCGAMVDSCIDHUVECPancreatic ductal adenocarcinomaPDAC یا pancreatic ductal adenocarcinomastandard deviationThe cancer genome atlaschromatin immunoprecipitationIHCImmunohistochemistryMicrovessel densityHuman umbilical vein endothelial cellConditioned mediumVascular endothelial growth factorVascular Endothelial Growth Factor (VEGF)Infiltrationanti-tumor immune responseTumor progressionCHiPsevere combined immunodeficiency
Related Topics
Health Sciences
Medicine and Dentistry
Gastroenterology
Authors
Chongbiao Huang, Zengxun Li, Na Li, Yang Li, Antao Chang, Tiansuo Zhao, Xiuchao Wang, Hongwei Wang, Song Gao, Shengyu Yang, Jihui Hao, He Ren,