Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8726917 | Gastroenterology | 2018 | 66 Pages |
Abstract
Mice with hepatocytes that express hREG3A, which travels to the intestinal lumen, are less sensitive to colitis than control mice. We found hREG3A to alter the colonic microbiota by decreasing levels of ROS. Fecal microbiota from REG3A-TG mice protect non-TG mice from induction of colitis. These findings indicate a role for reduction of oxidative stress in preserving the gut microbiota and its ability to prevent inflammation.
Keywords
LPSrRNAH2-DCFDAAMPsTNBSIBDGITDSS2′,7′-dichlorofluorescein diacetate2-[18F]fluoro-2-deoxy-d-glucose2,4,6-Trinitrobenzene sulfonic acidPCARibosomal RNAROS[18F]FDGlipopolysaccharide endotoxinBacteriaInflammatory bowel diseasePrincipal component analysisTransgenicGastrointestinal tractdextran sodium sulfateMouse modelwild-typeReactive oxygen species
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Authors
Marion Darnaud, Alexandre Dos Santos, Patrick Gonzalez, Sandrine Augui, Claire Lacoste, Christophe Desterke, Gert De Hertogh, Emma Valentino, Emilie Braun, Jinzi Zheng, Raphael Boisgard, Christel Neut, Laurent Dubuquoy, Franck Chiappini, Didier Samuel,