Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8727017 | Gastroenterology | 2018 | 16 Pages |
Abstract
Esophageal squamous cell carcinoma (ESCC) is a common malignancy without effective therapy. The exomes of more than 600 ESCCs have been sequenced in the past 4 years, and numerous key aberrations have been identified. Recently, researchers reported both inter- and intratumor heterogeneity. Although these are interesting observations, their clinical implications are unclear due to the limited number of samples profiled. Epigenomic alterations, such as changes in DNA methylation, histone acetylation, and RNA editing, also have been observed in ESCCs. However, it is not clear what proportion of ESCC cells carry these epigenomic aberrations or how they contribute to tumor development. We review the genomic and epigenomic characteristics of ESCCs, with a focus on emerging themes. We discuss their clinical implications and future research directions.
Keywords
EpigenomicsLong interspersed nuclear element-1IENAPOBECKlf5SMGHNSCCADARWESESCCFGFRCNACISNrf2BCHWhole-exome sequencingLINE-1Esophageal cancerkruppel-like factor 5Intraepithelial neoplasiaBasal cell hyperplasiaGenomicsCarcinoma in situSquamous cell carcinoma of the lungHead and neck squamous cell carcinomaEsophageal squamous cell carcinomaCopy number alterationfibroblast growth factor receptorLUSC
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Authors
De-Chen Lin, Ming-Rong Wang, H. Phillip Koeffler,