| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8727385 | Gastroenterology | 2017 | 14 Pages |
Abstract
BMI1 and MEL18 contribute to the development of CAC in mice by promoting proliferation and reducing apoptosis via suppressing expression of Reg3b. REG3B negatively regulates cytokine-induced activation of STAT3 in colon epithelial cells. This pathway might be targeted in patients with colitis to reduce carcinogenesis.
Keywords
PBSPAPPcG5-bromo-2-deoxyuridineCACDSSazoxymethaneAOMRT-PCRJanus kinaseBmi1chromatin immunoprecipitationBrdUstandard error of the meanintraperitonealcolitis-associated cancerColon cancerintestinal epithelial cellDextran sulfate sodiumCo-IPPhosphate-buffered salineSEMknockoutwild-typeCo-Immunoprecipitationreverse-transcription polymerase chain reactionJAKCHiPIECUlcerative colitispolycomb group
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Authors
Xicheng Liu, Wendi Wei, Xiaowei Li, Pengcheng Shen, Dapeng Ju, Zhen Wang, Rukui Zhang, Fu Yang, Chunyan Chen, Kun Cao, Guoli Zhu, Hongyan Chen, Liang Chen, Jianhua Sui, Erquan Zhang, Kaichun Wu, Fengchao Wang, Liping Zhao, Rongwen Xi,