| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8727504 | Gastroenterology | 2017 | 51 Pages |
Abstract
Levels of DHA-derived epoxides are lower in colon tissues from patients with UC than healthy and resolving mucosa. Production of these metabolites by gut endothelium requires MFSD2A; endothelial progenitor cells that overexpress MFSD2A reduce colitis in mice. This pathway might be induced to resolve intestinal inflammation in patients with colitis.
Keywords
Epoxydocosapentaenoic acidsEPAMFSD2aCOXECFCGFPTNFLNAIBDPUFAsCYP450TEERPCAAngiogenesisArachidonic acidEicosapentaenoic aciddocosahexaenoic acidLinolenic acidPolyunsaturated fatty acidsLOXinterleukinoverexpressingCrohn’s diseaseInflammatory bowel diseasePrincipal components analysisDHAhuman intestinal microvascular endothelial cellscytochrome P-450Cyclooxygenasesnuclear factortumor necrosis factorlipoxygenasestransendothelial electrical resistancegreen fluorescent proteinUlcerative colitis
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Authors
Federica Ungaro, Carlotta Tacconi, Luca Massimino, Paola Antonia Corsetto, Carmen Correale, Philippe Fonteyne, Andrea Piontini, Valeria Garzarelli, Francesca Calcaterra, Silvia Della Bella, Antonino Spinelli, Michele Carvello, Angela Maria Rizzo,