Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8727505 | Gastroenterology | 2017 | 41 Pages |
Abstract
In analyses of transgenic mice, we found TGF-β signaling to be required for formation of liver tumors upon expression of activated RAS and shRNA down-regulating p53, and upon expression of activated RAS and TAZ. Snail is the TGF-β target that is required for hepatic tumorigenesis in these models.
Keywords
TGF-βLHPRT-PCRPHImRNAeGFPshRNARNA-seqHCCmessenger RNAshort hairpin RNAOncogeneImmunohistochemistryIHCTransforming Growth Factor BetaRNA-sequencingTUNELEMTstandard error of the meanLiver cancerSEMMouse modelSignal transductionreverse-transcription polymerase chain reactionenhanced green fluorescent proteinHepatocellular carcinomaEpithelial-mesenchymal transition
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Authors
Hyuk Moon, Hye-Lim Ju, Sook In Chung, Kyung Joo Cho, Jung Woo Eun, Suk Woo Nam, Kwang-Hyub Han, Diego F. Calvisi, Simon Weonsang Ro,