| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8727506 | Gastroenterology | 2017 | 43 Pages |
Abstract
In analyses of paired blood and liver samples from patients with chronic HCV infection before, during, and after antiviral therapy with sofosbuvir and velpatasvir, we found that intrahepatic MAIT cells are activated by monocyte-derived cytokines and depleted in HCV-induced liver inflammation.
Keywords
PBSMucosal-associated invariant T cellsFBSFIB-4PBMCSVRIFN-γIQREMATCrEthidium monoazidestandard deviationtumor necrosis factor alphafetal bovine serumperipheral blood mononuclear cellsCirrhosisTNF-αinterquartile rangePhosphate-buffered salineImmune regulationMAITHCVHepatitis C virusResponse to treatmentInterferon gammaT cell receptor
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Authors
Fabian J. Bolte, Ashley C. O'Keefe, Lauren M. Webb, Elisavet Serti, Elenita Rivera, T. Jake Liang, Marc Ghany, Barbara Rehermann,