| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8727507 | Gastroenterology | 2017 | 12 Pages |
Abstract
In biochemical and histologic studies of plasma, liver, muscle, and adipose tissues from mice, we found that FFAs increase hepatic expression and secretion of MIR122, which regulates energy storage vs expenditure in liver and peripheral tissues. Strategies to reduce triglyceride levels, by increasing MIR122, might be developed for treatment of metabolic syndrome.
Keywords
NAFLDβ-hydroxybutyrateHFDFFASREBP-1cRORαHCCHnfAntagomirnonalcoholic steatohepatitisOleic acidFree fatty acidmiR-122Boron-dipyrrometheneTriglyceridesPosttranscriptional regulationBODIPYhigh-fat dietTranscription factorhepatocyte nuclear factorlauric acidUTR یا untranslated regions untranslated regionMicroRNAMiRNANash polymerase chain reactionPCRHepatocellular carcinoma
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Authors
Chofit Chai, Mila Rivkin, Liav Berkovits, Alina Simerzin, Elina Zorde-Khvalevsky, Nofar Rosenberg, Shiri Klein, Dayana Yaish, Ronen Durst, Shoshana Shpitzen, Shiran Udi, Joseph Tam, Joerg Heeren, Anna Worthmann, Christoph Schramm, Johannes Kluwe,