| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8727511 | Gastroenterology | 2017 | 51 Pages |
Abstract
We identified the aurora kinase inhibitor CCT137690 as an agent that induces necrosis-like death in PDAC cells, via RIPK1, RIPK3, and MLKL. CCT137690 slowed growth of orthotopic tumors from PDAC cells in mice, and expression of AURKA and GSK3β associate with patient survival times. AURKA might be targeted for treatment of pancreatic cancer.
Keywords
DAMPsMLKLHPDEGSK3βHMGB1TNFR1HEK293shRNAMEFaurora kinase Ashort hairpin RNAATPPDAC یا pancreatic ductal adenocarcinomaAURKAdamage-associated molecular patternsAntitumor immunityinterferonIFNICDRIPKmixed lineage kinase domain-likeImmunogenic cell deathregulated cell deathmouse embryonic fibroblastwild typehuman embryonic kidney 293glycogen synthase kinase 3 betatumor necrosis factor receptor 1
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Authors
Yangchun Xie, Shan Zhu, Meizuo Zhong, Manhua Yang, Xiaofan Sun, Jinbao Liu, Guido Kroemer, Michael Lotze, Herbert J. III, Rui Kang, Daolin Tang,