Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8730661 | Pancreatology | 2018 | 7 Pages |
Abstract
Interleukin-22 (IL-22) is involved in the development of lymphocytes and serves as a rapid and early source of the effector cytokines that are released in response to pathogen-induced changes in the microenvironment. Recent research has implicated IL-22 as a potential contributing factor to the spectrum of inflammation-related pancreatic diseases, particularly pancreatitis, fibrosis, carcinoma and diabetes. In this review, we summarize the current knowledge on the roles of IL-22 in the various pancreatic pathogenesis, providing insights into the underlying cellular and signaling mechanisms that will help guide future research into promising interventional targets with therapeutic potential.
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Authors
Xiuyun Xuan, Zhiqiang Tian, Mengjie Zhang, Jian Zhou, Weiwu Gao, Yi Zhang, Yue Zhang, Bo Lei, Bing Ni, Yuzhang Wu, Weiping Fan,