Recomendações da Sociedade Brasileira de Reumatologia para a terapia de indução para vasculite associada a ANCA

The purpose of these recommendations is to guide the appropriate induction treatment of AAV patients with active disease. The recommendations proposed by the Vasculopathies Committee of the Brazilian Society Rheumatology for induction therapy of antineutrophil cytoplasmic antibody‐associated vasculitis (AAV), including granulomatosis with polyangiitis, microscopic polyangiitis and renal‐limited vasculitis, were based on systematic literature review and expert opinion. Literature review was performed using Medline (PubMed), EMBASE and Cochrane database to retrieve articles until October 2016. PRISMA guidelines were used for the systematic review and articles were assessed according to the Oxford levels of evidence. Sixteen recommendations were made regarding different aspects of induction therapy for AAV. The purpose of these recommendations is to serve as a guide for therapeutic decisions by health care professionals in the management of AAV patients presenting active disease.