| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8733548 | Critical Reviews in Oncology/Hematology | 2018 | 13 Pages |
Abstract
In this review, we will describe the immunotherapeutic targets and modalities available and review the most recent immunotherapeutic clinical trials in the context of gynecological cancers. The synergic results obtained from the combination of HPV therapeutic vaccines with radiotherapy, chemotherapy, or immune checkpoint inhibitors, may underlie the potential for a novel therapeutic scenario for these tumors.
Keywords
CTLA-4PD-1cytotoxic T-lymphocyte-associated antigen 4PD-L1APCACTCervical intraepithelial neoplasiaClinical trialsAntigen presenting cellsAdoptive cell transferimmunotherapyCinEndometrial cancerCervical cancerGynecological cancersDendritic cellsVINImmune checkpoint blockademajor histocompatibility complexMHCVaginal intraepithelial neoplasiaVulvar intraepithelial neoplasiaHPV vaccinesVaINHuman papilloma virusHPV
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Authors
Chiara Di Tucci, Michele Carlo Schiavi, Pierangelo Faiano, Ottavia D'Oria, Giovanni Prata, Valentina Sciuga, Andrea Giannini, Innocenza Palaia, Ludovico Muzii, Pierluigi Benedetti Panici,