Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8735887 | Journal of Clinical and Experimental Hepatology | 2017 | 15 Pages |
Abstract
Matrix metalloproteinases (MMPs) are proteinases capable of degrading components of the extracellular matrix and numerous nonmatrix proteins. MMPs along with tissue inhibitors of MMPs, have been implicated in the pathogenesis of liver diseases. Although, the precise mechanism-of-actions of MMPs in various liver related disorders is largely unknown, however, data from diverse experimental models indicate that these proteinases influence cellular activities including proliferation and survival, gene expression, as well as multiple aspects of inflammation. Hence, MMP's are likely key players in the outcomes related to liver disease.
Keywords
ECMNAFLDTNFTissue inhibitors of MMPsTIMPsNFkBGBDMMPHCCIRIIschemia and reperfusion injuryGlobal burden of diseasenon-alcoholic fatty liver diseaseCirrhosistumor necrosis factornuclear factor kappa-BLiver fibrosisextra cellular matrixExtracellular matrix (ECM)Matrix metalloproteasesMatrix metalloproteinasesHepatocellular carcinomaCollagencol
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Authors
Adnan Naim, Qiuwei Pan, Mirza S. Baig,