Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8736346 | Autoimmunity Reviews | 2018 | 40 Pages |
Abstract
The main purpose of this article is to review the involvement of the protein quality control and unfolded protein response (UPR) in the ER protein homeostasis (proteostasis) and their alterations in autoimmune diseases. In addition, we describe the interaction between ER stress and inflammation and evidences are shown of how autoimmune diseases are associated with an ER stress condition, with a special emphasis on the second most prevalent autoimmune rheumatic disease, Sjögren's syndrome.
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Authors
MarÃa-José Barrera, Sergio Aguilera, Isabel Castro, Sergio González, Patricia Carvajal, Claudio Molina, Marcela A. Hermoso, MarÃa-Julieta González,