Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8736445 | Autoimmunity Reviews | 2018 | 18 Pages |
Abstract
According to our systematic review, 16 genes contribute significantly in patients with thrombotic primary APS when compared with controls. Bioinformatic analyses of these genes revealed their molecular interconnectivity in protein levels largely by affecting blood coagulation and immune system. These genes are expressed in 32 different organs and may pose higher risk of developing thrombosis anywhere in the body of primary APS patients.
Keywords
TNFADPTLRPBMCsPAI-1NOSvWFVEGFAβ2GPIPAMPsTFPIPAR-1STRINGtPAITGA2SELPFDRmRNAAPsmessenger RNAβ2-glycoprotein Iadenosine diphosphatePulmonary embolismApoHapolipoprotein HSearch Tool for the Retrieval of Interacting GenesExpressionpathogen-associated molecular patternsinterleukinBioinformatic analysisThrombosisDeep vein thrombosisDVTtoll like receptorACLperipheral blood mononuclear cellsAntiphospholipid syndromeanticardiolipinTissue factorVon Willebrand factortumour necrosis factorVascular endothelial growth factor Atissue plasminogen activatorSystemic lupus erythematosuslupus anticoagulantSLESystematic reviewNewcastle-Ottawa ScalePlasminogen activator inhibitor-1Tissue factor pathway inhibitorfalse discovery rateodds ratioGene ontologyGeneticsInterleukin-1 receptor-associated kinase
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Authors
Md. Asiful Islam, Shahad Saif Khandker, Fahmida Alam, Mohammad Amjad Kamal, Siew Hua Gan,