Genetic risk factors in thrombotic primary antiphospholipid syndrome: A systematic review with bioinformatic analyses

Article ID	Journal	Published Year	Pages	File Type
8736445	Autoimmunity Reviews	2018	18 Pages	PDF

Abstract

According to our systematic review, 16 genes contribute significantly in patients with thrombotic primary APS when compared with controls. Bioinformatic analyses of these genes revealed their molecular interconnectivity in protein levels largely by affecting blood coagulation and immune system. These genes are expressed in 32 different organs and may pose higher risk of developing thrombosis anywhere in the body of primary APS patients.

Keywords

TNF ADP TLR PBMCs PAI-1 NOS vWF VEGFA β2GPI PAMPs TFPI PAR-1 STRING tPA ITGA2 SELP FDR mRNA APs messenger RNA β2-glycoprotein I adenosine diphosphate Pulmonary embolism ApoH apolipoprotein H Search Tool for the Retrieval of Interacting Genes Expression pathogen-associated molecular patterns interleukin Bioinformatic analysis Thrombosis Deep vein thrombosis DVT toll like receptor ACL peripheral blood mononuclear cells Antiphospholipid syndrome anticardiolipin Tissue factor Von Willebrand factor tumour necrosis factor Vascular endothelial growth factor A tissue plasminogen activator Systemic lupus erythematosus lupus anticoagulant SLE Systematic review Newcastle-Ottawa Scale Plasminogen activator inhibitor-1 Tissue factor pathway inhibitor false discovery rate odds ratio Gene ontology Genetics Interleukin-1 receptor-associated kinase