| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8736446 | Autoimmunity Reviews | 2018 | 29 Pages |
Abstract
In conclusion, we observed an altered B-cell homeostasis in SSc patients compared to HC. Memory B-cells were both decreased and activated in patients. IL-10 producing B-cells were decreased in SSc. This decrease was associated with an alteration of mTOR phosphorylation in B-cells. Conversely, there was no correlation between serum cytokine profile and B-cell homeostasis alterations.
Related Topics
Life Sciences
Immunology and Microbiology
Immunology
Authors
Alexandra Forestier, Thomas Guerrier, Mathieu Jouvray, Jonathan Giovannelli, Guillaume Lefèvre, Vincent Sobanski, Carine Hauspie, Eric Hachulla, Pierre-Yves Hatron, Hélène Zéphir, Patrick Vermersch, Myriam Labalette, David Launay, Sylvain Dubucquoi,