Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8736948 | Current Opinion in Immunology | 2018 | 8 Pages |
Abstract
Type 2 immune responses contribute to the resistance to helminths and toxins as well as several physiological processes. Although they usually do not participate in type 2 immune responses, neutrophils have been shown in mice to enhance the anti-helminth response, but they also contribute to increased target tissue damage. Increased pathology and morbidity is also observed in type 2 immune-mediated disorders, such as allergic asthma, when neutrophils become a predominant subset of the infiltrate. How neutrophil recruitment is regulated during type 2 immune responses is now starting to become clear, with recent data showing that signaling via the prototypic type 2 cytokine interleukin-4 receptor mediates direct and indirect inhibitory actions on neutrophils in mice and humans.
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Authors
Lukas E M Heeb, Cecilie Egholm, Daniela Impellizzieri, Frederike Ridder, Onur Boyman,