Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8737424 | Diagnostic Microbiology and Infectious Disease | 2017 | 18 Pages |
Abstract
IncX-type plasmids have achieved clinical significance for their contribution in the dissemination of genes confering resistance to carbapenems (most blaKPC- and blaNDM-type genes) and polymyxins (mcr-type genes), both antibiotics considered last resort for multidrug-resistant Gram-negative infections. In this study, we report the identification and complete sequence analysis of an IncX3 plasmid (designated pKP1194a) carrying a non-Tn4401 genetic element (NTEKPC) of tnpR-tnpA (partial)-blaKPC-2-ÎISKpn6/traN, originating from a hospital-associated lineage of K. pneumoniae belonging to the ST340/CG258, with epidemiological link to Brazil.
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Authors
Louise T. Cerdeira, Marcos P.V. Cunha, Gabriela R. Francisco, Maria Fernanda C. Bueno, Bruna F. Araujo, Rosineide M. Ribas, Paulo P. Gontijo-Filho, Terezinha Knöbl, Doroti de Oliveira Garcia, Nilton Lincopan,