Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8737728 | Human Immunology | 2017 | 16 Pages |
Abstract
We assessed 81 healthy adults and 82 RTR >2â¯years after transplantation. RTR had higher humoral and T-cell responses to CMV, and impaired vascular health. A 14bp indel in HLA-G associated with increased flow-mediated dilatation of the brachial artery. The T allele of LILRB1 rs1061680 associated with increased carotid intimal media thickness (cIMT) in RTR and controls. A 16â¯kb deletion encompassing the NKG2C gene associated with lower cIMT values and higher humoral and T-cell responses to CMV. Hence all polymorphisms tested had small but discernable effects on vascular health. The NKG2C deletion may act via CMV.
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Authors
Shelley Waters, Silvia Lee, Jacquita S. Affandi, Ashley Irish, Patricia Price,