Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8738291 | Immunology Letters | 2018 | 7 Pages |
Abstract
The mechanisms for dominant T15 idiotype selection are not well understood, yet the significance of idiotypic regulation has been suggested. We proposed that to become dominant V regions of a given subset of B-1a cell must establish a functional idiotypic network with complementary T cells. Features required for the cells involved in immune network and steps preceding the establishment of clonal dominance are suggested.
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Authors
R. Metlas, T. Srdic-Rajic, H. Kohler,