Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8738441 | International Journal of Antimicrobial Agents | 2018 | 12 Pages |
Abstract
TP-6076 is a synthetic fluorocycline antibiotic that inhibits bacterial protein synthesis. In this study, carbapenem-resistant Acinetobacter baumannii clinical isolates from 13 Greek hospitals were tested for susceptibility to TP-6076 and comparator antibiotics. Broth microdilution plates were used to determine minimum inhibitory concentrations (MICs). A total of 121 non-duplicate A. baumannii isolates were tested. The MIC50 and MIC90 values of TP-6076 were 0.03 mg/L and 0.06 mg/L, respectively. Tigecycline was the second most active antibiotic (MIC90, 2 mg/L), followed by minocycline (MIC90, 8 mg/L). TP-6076 exhibited MIC90 values that were one dilution lower against tigecycline- and minocycline-susceptible isolates than against resistant isolates. There was no difference in the MIC90 value for colistin-susceptible or -resistant isolates. In conclusion, TP-6076 exhibited greater antimicrobial activity in vitro against carbapenem-resistant A. baumannii than comparator antibiotics.
Keywords
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Applied Microbiology and Biotechnology
Authors
Matthew E. Falagas, Tilemachos Skalidis, Konstantinos Z. Vardakas, Georgios L. Voulgaris, Georgios Papanikolaou, Nicholas Legakis, The Hellenic TP-6076 Study Group The Hellenic TP-6076 Study Group,