| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8738547 | International Journal of Antimicrobial Agents | 2018 | 45 Pages |
Abstract
- Inhibitors of resistance enzymes can extend the life of existing aminoglycosides.
- Identification of novel inhibitors using mixture-based combinatorial libraries.
- A substituted pyrrolidine pentamine significantly reduces resistance to amikacin.
Keywords
Related Topics
Life Sciences
Immunology and Microbiology
Applied Microbiology and Biotechnology
![Identification of a small molecule inhibitor of the aminoglycoside 6'-N-acetyltransferase type Ib [AAC(6')-Ib] using mixture-based combinatorial libraries](/preview/png/8738547.png "First Page Preview: Identification of a small molecule inhibitor of the aminoglycoside 6'-N-acetyltransferase type Ib [AAC(6')-Ib] using mixture-based combinatorial libraries")
Authors
Tung Tran, Kevin Chiem, Saumya Jani, Brock A. Arivett, David L. Lin, Rupali Lad, Verónica Jimenez, Mary B. Farone, Ginamarie Debevec, Radleigh Santos, Marc Giulianotti, Clemencia Pinilla, Marcelo E. Tolmasky,