Paracoccidioidomycosis simulating Crohn's disease

- Paracoccidioidomycosis should be considered in the differential diagnosis of colonic lesions that mimic Crohn's disease in patients from endemic countries, before the start of immunosuppressive therapy.
- Molecular diagnostic methods such as panfungal PCR can be useful in the diagnosis of invasive fungal infections.
- Serological techniques may be a good option paracoccidioidomicosis diagnosis, however their specificity and sensitivity vary depending on the type of antigen used.