Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8739498 | Journal of Autoimmunity | 2018 | 10 Pages |
Abstract
We demonstrate a fundamental role for 11β-HSD1 in the suppression of synovitis, joint destruction, and systemic bone loss. Whilst a role for 11β-HSD1 inhibitors has been proposed for metabolic complications in inflammatory diseases, our study suggests that this approach would greatly exacerbate disease severity.
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Authors
R.S. Hardy, C. Fenton, A.P. Croft, A.J. Naylor, R. Begum, G. Desanti, C.D. Buckley, G. Lavery, M.S. Cooper, K. Raza,