Article ID Journal Published Year Pages File Type
8741533 Osteoarthritis and Cartilage 2018 33 Pages PDF
Abstract
Chronic TLR4 inhibition decreased behavioral signs of LBP, pain-related neuroplasticity and disc inflammation in SPARC-null mice. TAK-242 inhibits TLR4 activation within discs, as evidenced by decreases in cytokine release. Therefore, TLRs are potential therapeutic targets to slow disc degeneration and reduce pain.
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Related Topics
Health Sciences Medicine and Dentistry Immunology, Allergology and Rheumatology
Preview
Low back pain and disc degeneration are decreased following chronic toll-like receptor 4 inhibition in a mouse model
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