Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8741534 | Osteoarthritis and Cartilage | 2018 | 10 Pages |
Abstract
Based on the immune cell composition of SFs, data mining analysis revealed distinct phenotypes (monocyte- and lymphocyte-predominant) within each gender group. This first study on the cellular complexity of SFs in KOA showed marked differences between male and female patients. The findings give a rational starting point for patient stratification according to their phenotypes, as is required for phenotype-specific treatment strategies.
Keywords
MMPSSC-AFSC-ATKATIMP-1TregMDCKOADAFSSCASCFSCPBSLPSMFIPDCBSAT regulatoryArthroscopyTotal knee arthroplastyRheumatoid arthritisKnee osteoarthritisOsteoarthritisImmunophenotypingtissue inhibitor of metalloproteinase-1ACLAnterior cruciate ligamentbovine serum Myeloid dendritic cellplasmacytoid dendritic cellsmedian fluorescence intensityDecay-accelerating factorLymphocyteslipopolysaccharidematrix metalloproteinaseMast cellMacrophagesynovial fluidPhosphate-buffered salineNeutrophilsforward scatterside scatter
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Authors
E. Kriegova, G. Manukyan, Z. Mikulkova, G. Gabcova, M. Kudelka, P. Gajdos, J. Gallo,