Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8741579 | Osteoarthritis and Cartilage | 2018 | 40 Pages |
Abstract
Wnt5a, which can be induced by TNF-α, increased matrix production in a Sox9-dependent manner through the activation of JNK-AP1 (JunB) signaling, and antagonized TNF-α-induced up-regulation of MMPs through the inhibition of NF-κB signaling. It indicates that Wnt5a suppresses IVDD through a TNF-α/NF-κB-Wnt5a negative-feedback loop.
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Authors
Z. Li, K. Zhang, X. Li, H. Pan, S. Li, F. Chen, J. Zhang, Z. Zheng, J. Wang, H. Liu,