Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8741580 | Osteoarthritis and Cartilage | 2018 | 29 Pages |
Abstract
Our findings show that in IVD degenerative microenvironment, IL-8, NGF, IFN-γ, IL-17 drive activation of microglia in the spinal cord and increase upregulation of neuroinflammatory markers. This, in turn, enhances the inflammatory milieu within IVD tissues and in the peridiscal space, aggravating the cascade of degenerative events. This study provides evidence for an important role of microglia in maintaining IVD neuroinflammatory microenvironment and probably inducing low back pain.
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Authors
S.E. Navone, M. Peroglio, L. Guarnaccia, M. Beretta, S. Grad, M. Paroni, C. Cordiglieri, M. Locatelli, M. Pluderi, P. Rampini, R. Campanella, M. Alini, G. Marfia,