| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8741597 | Osteoarthritis and Cartilage | 2018 | 28 Pages |
Abstract
We have firmly established the identity of CCAL1 as TNFRSF11B (OPG). Our findings suggest that this mutation produces disease in an ANKH-independent manner via novel mechanisms not primarily targeting cartilage. This work rationalizes further investigation of OPG pathway components as potential druggable targets for CPDD.
Keywords
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Authors
C.J. Williams, U. Qazi, M. Bernstein, A. Charniak, C. Gohr, E. Mitton-Fitzgerald, A. Ortiz, L. Cardinal, A.T. Kaell, A.K. Rosenthal,