Synovial and systemic pharmacokinetics (PK) of triamcinolone acetonide (TA) following intra-articular (IA) injection of an extended-release microsphere-based formulation (FX006) or standard crystalline suspension in patients with knee osteoarthritis (OA)

Article ID	Journal	Published Year	Pages	File Type
8741730	Osteoarthritis and Cartilage	2018	36 Pages	PDF

Abstract

In knee OA patients, microsphere-based TA delivery via a single IA injection prolonged SF joint residency, diminished peak plasma levels, and thus reduced systemic TA exposure relative to TAcs.

Keywords

Synovium Knee osteoarthritis triamcinolone Pharmacokinetics Intra-articular Corticosteroid

Related Topics

Health Sciences Medicine and Dentistry Immunology, Allergology and Rheumatology

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Synovial and systemic pharmacokinetics (PK) of triamcinolone acetonide (TA) following intra-articular (IA) injection of an extended-release microsphere-based formulation (FX006) or standard crystalline suspension in patients with knee osteoarthritis (OA)

Authors

V.B. Kraus, P.G. Conaghan, H.A. Aazami, P. Mehra, A.J. Kivitz, J. Lufkin, J. Hauben, J.R. Johnson, N. Bodick,