Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8742710 | Revista Colombiana de Reumatología | 2018 | 8 Pages |
Abstract
Anti-DFS70 antibodies (Dense Fine Speckled, 70Â kd molecular weight) are a sub-group of anti-nuclear antibodies (ANA) that show a fine dense speckled pattern (DFS) by indirect immunofluorescence. This pattern is also recognised by irregularly distributed granular fluorescence at the interface of nuclei and chromatin. This antibody was initially described in patients with interstitial cystitis, atopic dermatitis, and malignancy, such as prostate cancer. These antigens have been found to act directly against co-activators of nuclear transcription (LEDGF/p75) encoded by the PSP1 gene and located in the C-terminal region between the a.a. 349 and 435. Additionally, associations with some physiological functions have been described, such as protection against stress-induced apoptosis, the survival of lens epithelial cells, and acting as a cofactor of HIV replication through its interaction with viral integrase. As regards autoimmunity, recent evidence has also shown the importance of this antibody as a useful biological marker in the discrimination of individuals with positive ANA that do not progress to systemic autoimmune disease (SID). This is based on the observation that these antibodies are more common in healthy individuals than in patients with SID, and that healthy individuals with positive anti-DFS70 did not develop SIDs after a clinical follow-up of four years or more. This article reviews the description of anti-DFS70 and its usefulness in clinical practice.
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Authors
Cristian-Camilo Aragón, Juan David González, Iván Posso-Osorio, Juan Naranjo-Escobar, Germán Puerta, Alex Echeverri, Eliana Ortiz, Gabriel J. Tobón,