Rôle des cofacteurs dans l'anaphylaxie alimentaire

The cofactors of anaphylaxis, seen in up to 30% of cases, require screening for any of the aggravating circumstances that can cause the most severe clinical reactions. Drugs play a key role in this respect, with the following having all been incriminated: NSAIDs, beta-blockers, ACE inhibitors, sartans; and more recently, proton-pump inhibitors and statins. Certain situations such as acute infections, exercise, alcohol consumption and patients comorbidities (e.g. asthma, cardiovascular disease, mastocytosis) constitute further identified cofactors. Finally, the effect of certain hormones such as estrogens has recently been highlighted as an instrumental factor in the severity of anaphylaxis.