Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8743676 | Seminars in Immunology | 2018 | 13 Pages |
Abstract
The present review summarises the current view on the role of the complement cascade on bone, both under homeostatic physiological conditions and under inflammatory and infectious conditions, which strongly affect the bone and skeletal health. Furthermore, this review addresses the potential and the feasibility of therapeutic interventions involving the complement cascade, derived from experimental and clinical data. Modulating the complement system could help in the future to reduce bone infections, ensure a balanced bone turnover and to generally improve skeletal health.
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Authors
Yvonne Mödinger, Bettina Löffler, Markus Huber-Lang, Anita Ignatius,