Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8743698 | Seminars in Immunology | 2018 | 11 Pages |
Abstract
Fibroblasts in secondary lymphoid organs, or fibroblastic reticular cells (FRC), are gate-keepers of immune responses. Here, we frame how these cells regulate immune responses via a three-part scheme in which FRC can setup, support or suppress immune responses. We also review how fibroblasts from non-lymphoid tissues influence immunity and highlight how they resemble and differ from FRC. Overall, we aim to focus attention on the emerging roles of lymphoid tissue and non-lymphoid tissue fibroblasts in control of innate and adaptive immunity.
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Authors
Matthew B. Buechler, Shannon J. Turley,