Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8743769 | Transplant Immunology | 2018 | 11 Pages |
Abstract
Inhibition of the 5HT/5-HT2A receptor axis leads to significantly reduced neointima proliferation after aortic transplantation associated with reduced transendothelial migration of macrophages and decreased expression of inflammatory cytokines. These findings have translational implications as inhibitors of 5HT2A like sarpogrelate are already approved for clinical use.
Related Topics
Life Sciences
Immunology and Microbiology
Immunology
Authors
Annika Gocht, Jörg H.W. Distler, Bernd Spriewald, Martina Ramsperger-Gleixner, Michael Weyand, Stephan M. Ensminger, Christian Heim,