Persistent accumulation of circulating monocytic myeloid-derived suppressor cells contributes to post-infectious immunosuppression in renal transplant recipients with bacterial infection: A pilot study

Article ID	Journal	Published Year	Pages	File Type
8743776	Transplant Immunology	2018	21 Pages	PDF

Abstract

Circulating M-MDSCs underwent significant and persistent increases after bacterial infection in renal transplant recipients, contributing to post-infectious immunodeficiency. Therefore, special attention should be given to M-MDSCs during the monitoring of immune status and infection management.

Keywords

DGF RATG TGF-β Monocytic myeloid-derived suppressor cells ARG-1 L-NMMA FMO PICs MDSCs CFSE ARDS IDO PBMCs MMF RT-qPCR iNOS DSAS CDC arginase 1 donor-specific antibodies standard deviation polycystic kidney disease delayed graft function transforming growth factor-beta peripheral blood mononuclear cells Myeloid-derived suppressor cells complement-dependent cytotoxicity inducible nitric oxide synthase Acute respiratory distress syndrome Compensatory anti-inflammatory response syndrome CMV cytomegalovirus body mass index BMI fluorescence minus one CARS mycophenolate mofetil not significant reverse transcription-polymerase chain reaction Renal transplant carboxyfluorescein succinimidyl ester