| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8743781 | Transplant Immunology | 2018 | 8 Pages |
Abstract
Complement- and apoptosis-related gene expression is elevated in deceased donor transplants before transplantation. High BAX:BCL2 ratio and TLR4 expression during AR may reflect enhanced intragraft cell death and immunogenic danger signals, and pose a risk factor for adverse graft outcome.
Keywords
HMGB1ischemic renal injuryDGFBcl2ATGPAMPHspDAMPGAPDHIRIFFPETLRsdamage-associated molecular patternspathogen-associated molecular patternsBaxGene expressiondelayed graft functionApoptosisAcute rejection95% confidence intervalformalin-fixed and paraffin-embeddedB-cell lymphoma 2Toll like receptorsComplementMAChazard ratioBcl-2-associated X proteinHigh-mobility group box 1 proteinHeat-shock proteinsmembrane attack complexantithymocyte globulinsglyceraldehyde 3-phosphate dehydrogenaseToll-like receptors
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Authors
Jianxin Yang, Malou L.H. Snijders, Geert W. Haasnoot, Cees van Kooten, Marko Mallat, Johan W. de Fijter, Marian C. Clahsen-van Groningen, Frans H.J. Claas, Michael Eikmans,