In vitro 4-Aryloxy-7-chloroquinoline derivatives are effective in mono- and combined therapy against Leishmania donovani and induce mitocondrial membrane potential disruption

Article ID	Journal	Published Year	Pages	File Type
8744244	Acta Tropica	2018	30 Pages	PDF

Keywords

QII MtF AMB ΔΨm FIC IC50 PBS MIC 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide DMSO MTT Amphotericin B Synergistic effect Drug combinations Dimethyl sulfoxide Interaction index Leishmania Phosphate-buffered saline Miltefosine half maximal inhibitory concentration Mitochondrial membrane potential

Related Topics

Life Sciences Immunology and Microbiology Parasitology

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In vitro 4-Aryloxy-7-chloroquinoline derivatives are effective in mono- and combined therapy against Leishmania donovani and induce mitocondrial membrane potential disruption

Authors

Elizabeth Valdivieso, Fabiola MejÃas, Carlos Torrealba, Gustavo Benaim, Vladimir V. Kouznetsov, Felipe Sojo, Fernando A. Rojas-Ruiz, Francisco Arvelo, Francehuli Dagger,