Article ID Journal Published Year Pages File Type
874789 Journal of Biomechanics 2006 5 Pages PDF
Abstract

Microdamage accumulation leads to reduced bone strength and fracture. Intact, damaged and Rose Bengal stained cortical bone specimens were studied using SEM and EDXA imaging. SEM coupled with EDXA studies showed selective labelling of surface damage due to binding of dye at free lattice sites. A series of novel iodinated X-ray contrast agent were synthesised. These agents demonstrated excellent stability, water solubility and lack of atropisomerism. Preliminary imaging studies, using cone-beam μ-CT, demonstrated their ability to provide visible contrast in the solid state on bone surfaces.

Related Topics
Physical Sciences and Engineering Engineering Biomedical Engineering
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