Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8749102 | Microbes and Infection | 2018 | 12 Pages |
Abstract
Autophagy is a cellular process for maintaining cellular homeostasis. This process can be induced by different factors, such as immune stimuli and pathogen-associated molecules. Autophagy has an important role in the control of IL-1β secretion by macrophages and other cell types. In present study, we describe a novel role for Iraqi propolis affecting autophagy in controlling the secretion of IL-1β in bone-marrow macrophages (BMDMs). After infection with Pseudomonas aeruginosa in the presence of propolis, the degradation of IL-1β was induced, and the activity of inflammasome was reduced. Iraqi propolis-induced autophagy in in vitro and in vivo models decreased the levels of IL-1β and caspase-1. Results indicated that IL-1β pathway production is regulated by autophagy via two different novel mechanisms, namely, regulation of the activation of NLRC4 inflammasome and IL-1β targeting for lysosomal degradation.
Related Topics
Life Sciences
Immunology and Microbiology
Immunology
Authors
Majid S. Jabir, Ghassan M. Sulaiman, Zainab J. Taqi, Dong Li,